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Bitter melon is a vining plant that’s a member of the Cucurbitaceae family, which also includes squash, watermelon, and cucumbers. It’s no surprise that bitter melon tastes bitter. In fact, it can make your mouth pucker like sucking on a lemon. It tastes like a mixture of grapefruit and chocolate, if you can imagine that. The unripe version is eaten like a vegetable in dishes like stir fry.